在患有自闭症谱系障碍的个体中,逆复合体中的非典型场景选择性
Andrew S Persichetti1, Taylor L Li1, W Dale Stevens2
1Section on Cognitive Neuropsychology, Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
bioRxiv : the preprint server for biology
|January 13, 2025
概括
患有自闭症谱系障碍 (ASD) 的人在回复合体 (RSC) 中表现出较弱的场景选择性,影响记忆引导导航. 在部位区域 (OPA) 中没有观察到这种差异.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 发展心理学 发展心理学
背景情况:
- 患有自闭症谱系障碍 (ASD) 的人表现出导航障碍,特别是在记忆引导的策略中.
- 在典型发育 (TD) 个体中神经成像涉及回复合体 (RSC) 在记忆引导导航和部位区域 (OPA) 在视觉引导导航中.
- 无论是RSC还是OPA,都表现出场景选择性,更多地响应地点,而不是面孔或物体.
研究的目的:
- 调查RSC和OPA中与ASD和TD控制对象之间的场景选择性的差异.
- 确定RSC中场景选择性降低是否与ASD中记忆引导导航受损有关.
- 测试假设OPA中的场景选择性在ASD患者中保持不变的假设.
主要方法:
- 功能磁共振成像 (fMRI) 用于扫描患有自闭症的个体,并匹配TD对照.
- 参与者在执行单背任务时查看地点和面部图像.
- 场景选择性是通过比较大脑对地方和面部的反应来量化.
主要成果:
- 与TD组相比,ASD组的RSC显著减少了场景选择性.
- 在OPA中,ASD和TD组之间的场景选择性没有显著差异.
- 这些发现支持在ASD患者中预测非典型的RSC功能.
结论:
- 在ASD中受损的记忆引导导航可能部分归因于RSC的异常功能.
- 在ASD和TD个体中,OPA似乎在场景处理方面具有相似的功能.
- 这些结果突出了与自闭症谱系障碍中的空间导航相关的特定神经差异.
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