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Updated: Jun 2, 2025

Fluorescence-Based Measurements of Phosphatidylserine/Phosphatidylinositol 4-Phosphate Exchange Between Membranes
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非正规PI ((4,5) P2通过胆固醇贩运协调溶酶体定位

Ryan M Loughran1, Gurpreet K Arora1, Jiachen Sun2

  • 1Cancer Center, Sanford Burnham Prebys Medical Discovery Institute; La Jolla, CA, USA.

bioRxiv : the preprint server for biology
|January 13, 2025
PubMed
概括

这项研究揭示了PI5P4Ks对溶酶体胆固醇运输和p53缺乏癌症中的mTOR信号传递至关重要. 准PI5P4Ks提供了一种破坏胆固醇平衡和打击癌症生长的新策略.

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