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Updated: Jul 20, 2026

Quantitative High-throughput Single-cell Cytotoxicity Assay For T Cells
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Quantitative High-throughput Single-cell Cytotoxicity Assay For T Cells

Published on: February 2, 2013

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一个整合多尺度in-silico建模和实验数据的框架预测了跨细胞类型的CD33CAR-NK细胞毒性

Saeed Ahmad1, Kun Xing2,3, Harshana Rajakaruna1

  • 1Steve and Cindy Rasmussen Institute for Genomic Medicine, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH.

bioRxiv : the preprint server for biology
|January 13, 2025
PubMed
概括

我们开发了一个计算模型来预测CAR-NK细胞治疗的疗效. 这个工具准确地预测瘤细胞的死亡,通过了解复杂的免疫细胞相互作用,优化癌症治疗.

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相关概念视频

Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...