服用阿司匹林可降低白果者癌症风险:全国基于人口的队列研究
Peng Tien1, Zen Lang Bih2, Wan-Ming Chen3,4
1Department of Otorhinolaryngology, Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital Yilan 265, Taiwan.
阿司匹林的使用显著降低了贝特尔坚果的癌症风险. 较高的阿司匹林剂量与更大的风险降低相关,这表明它有可能成为这种高风险组的癌症化学预防剂.
科学领域:
- 在瘤学瘤学.
- 预防医学 预防医学
- 流行病学 流行病学
背景情况:
- 贝特尔坚果在亚洲普遍存在,并与增加口腔,食道,胃和肝癌的风险密切相关.
- 阿司匹林因其对各种癌症的潜在化学预防性质而闻名.
- 了解贝特尔坚果消费,阿司匹林使用和癌症发病率之间的相互作用对于公共卫生干预至关重要.
研究的目的:
- 研究阿司匹林使用与在贝特尔坚果的个体中患癌症的风险之间的关联.
- 为了确定阿司匹林的使用是否会改变已知的高风险行为的人群中的癌症风险.
主要方法:
- 分析了46,302名贝特尔坚果者 (年龄18岁以上) 的队列,阿司匹林使用量被定义为至少28个累积定义每日剂量 (cDDD).
- 倾向性得分匹配用于平衡阿司匹林使用者和非使用者之间的基线特征.
- 为了评估癌症风险,使用了经时间变化的协变量调整的考克斯比例危险模型.
主要成果:
- 阿司匹林使用与总体癌症风险显著减少31%有关 (aHR,0.69;95% CI,0.66-0.73).
- 观察到明显的剂量反应关系;较高的累积阿司匹林剂量 (cDDDs) 导致更大的癌症风险降低.
- 使用阿司匹林的最高四分位数显示,癌症风险降低了62% (aHR,0.38;95% CI,0.34-0.41).
结论:
- 阿司匹林的消费显著降低了白菜坚果者的整体癌症风险.
- 降低风险取决于剂量,服用更多的阿司匹林可以提供更大的保护.
- 这些发现支持阿司匹林作为一种化学预防剂的潜在作用,在参与高风险行为的人群中,如贝特尔坚果.
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