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用血清生物标志物评估肠道透性,以早期了解花生过敏试验

Ozge Nur Aktas^1,2, Allyson Mateja³, Min Jenny Li¹

¹Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, Maryland, USA.

|January 13, 2025

概括

在食物过敏 (FA) 和对照的婴儿中,肠道透性 (IP) 类似. 早期引入花生并没有改变敏感儿童的IP,这表明IP不是FA发展的关键因素.

科学领域:

免疫学免疫学免疫学
胃肠病学胃肠病学
儿科儿科儿科

背景情况:

肠道屏障功能障碍与食物过敏 (FA) 的发展有关.
在IgE介导的FA中,关于肠道透性的证据是相互矛盾的.
在患有湿疹和FA的婴儿中调查IP至关重要.

研究的目的:

为了确定IP是否在患有FA的湿疹儿童与对照儿童之间有所不同.
评估花生敏感化,过敏和早期引入对IP的影响.
使用血清生物标志物 (素,可溶性CD14,肠脂肪酸结合蛋白) 进行IP评估.

主要方法:

血清肠道透性标记物 (sIPM) 通过ELISA测量在FA受试者和亚托皮对照 (AC) 中.
参与者来自早期学习关于花生过敏的试验.
分析涉及参数测试和线性回归模型,将sIPM与临床特征相关联.

主要成果:

在FA受试者和AC在基线或60个月之间没有发现sIPM水平的显著差异.
发病时的年龄,湿疹的严重程度,花生敏感性/过敏性和早期引入花生与sIPM水平没有相关性.
总IgE,乙素,花生特异性IgE,IgG4和IgG4/IgE比率也与sIPM水平没有相关性.

结论:

与对照人群相比,在患有FA的婴儿中没有检测到改变肠道透性 (IP).
早期引入花生对花生敏感儿童的IP没有影响.
血清生物标志物不支持改变的IP在这个队列中FA的发展中的作用.

关键词:

亚托邦性皮肤炎的发生.湿疹和湿疹是一个问题.食物过敏食物过敏肠道的通透性肠道的通透性血清中的生物标志物

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