诊断测试对患有反症候群的儿童结果的影响
Janice S Khoo1, Ashley M Kroon Van Diest2,3, Dennis Yang1,3
1Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Nationwide Children's Hospital, Columbus, Ohio, USA.
Journal of pediatric gastroenterology and nutrition
|January 13, 2025
概括
经过诊断测试的反综合征 (RS) 儿童的治疗结果与没有测试的儿童相似. 需要进一步的研究,以了解反症候群患者的严重程度的基线差异.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 功能性胃肠道疾病 功能性胃肠道疾病
背景情况:
- 化综合征 (RS) 是一种通过临床标准诊断的疾病,有时由诊断测试支持,如腹腔门测量 (ADM),高分辨率食道测量 (HREM) 和多通道内阻抗-pH测试 (MII-pH).
- 这些诊断测试在预测RS治疗结果中的临床实用性尚不清楚.
研究的目的:
- 这项研究旨在评估反综合征的确认诊断测试与儿科患者的临床结果之间的相关性.
- 为了比较RS的儿童的治疗反应,这些儿童的诊断得到证实,与那些临床诊断的儿童相比.
主要方法:
- 对152名被诊断患有RS的儿科患者进行了回顾性审查.
- 患者被分为两组:具有诊断测试证实RS (ADM,HREM和/或MII-pH) 的患者和没有的患者.
- 通过比较治疗后停止吐并不再需要补充营养的患者比例来评估治疗反应.
主要成果:
- 在152名RS儿童中,22名 (14%) 接受了确认性诊断测试.
- 得到确认测试的组在基线时更有可能需要补充营养和密集治疗.
- 在治疗后,两组患者在吐,症状报告和营养支持需求方面都有相似的改善.
结论:
- 儿童反综合征的确认诊断测试并没有显著改变吐停止的治疗结果.
- 接受诊断测试的RS儿童的病情改善的可能性与没有测试的儿童一样大.
- 未来的研究应该在反症候群研究中解决这些群体之间潜在的基线严重程度差异.
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