大脑功能网络的拓特征在慢性耳声期间被重组:图形理论研究
Shuting Han1, Yongcong Shen2, Xiaojuan Wu1
1Department of Radiology, the First Affiliated Hospital of Soochow University, Suzhou, China.
The European journal of neuroscience
|January 13, 2025
概括
最近出现的耳声会改变大脑网络的拓结构,特别是影响局部效率和连接. 然而,随着耳变得持久,大脑中的这些拓变化似乎正常化.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 网络科学 网络科学
背景情况:
- 耳,一个幻象的听觉感知,影响全球数百万人.
- 了解 tinnitus 的神经支,特别是关于其持续时间,对于开发有针对性的疗法至关重要.
- 大脑功能网络拓学为与耳相关的神经变化提供了见解.
研究的目的:
- 调查最近出现的耳 (ROT) 和持续的耳 (PT) 的患者大脑功能网络的拓性特性.
- 为了比较 tinnitus 组和健康对照组 (HC) 之间的网络变化.
- 为了确定 tinnitus 持续时间是否会影响大脑网络拓.
主要方法:
- 招募了51名耳患者 (ROT和PT组) 和27名健康对照 (HC).
- 获得了所有参与者的休息状态功能性MRI数据.
- 应用图形理论来分析大脑网络拓,包括集群系数,效率和连接性.
主要成果:
- 与HC和PT组相比,最近出现的耳患者的聚类系数,玛,西格玛和局部效率明显较低.
- ROT患者在特定的大脑区域 (例如,左尾状核,左嗅觉皮层) 显示节点聚类和局部效率降低.
- 与HC相比,持久性耳患者表现出改变的模块间连接 (下皮层 - 皮层,前额叶 - 内额叶),但在下皮层模块内具有更强的模块内连接.
结论:
- 最近出现的耳声的特点是大脑功能网络拓学的明显变化.
- 在最近出现的耳声中观察到的许多拓变化,似乎随着耳声的持久性而恢复或改变.
- 大脑网络的重组可能在从最近出现的耳转变为持续的耳中发挥作用.
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