循环Treg和血微RNA-21与类风湿性关节炎进展的关联
Mariam Gamal1, Ola El-Diwany2, Sally S Abd Elhamed3
1Department of Clinical Pathology, AboEl Azayem Hospital, Cairo, Egypt.
The Egyptian journal of immunology
|January 13, 2025
概括
调节性T细胞 (Treg) 功能障碍和增加的microRNA-21 (miR-21) 与类风湿性关节炎 (RA) 活动有关. 较低的Treg频率和较高的miR-21水平可以作为RA进展的生物标志物.
科学领域:
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
- 类风湿病学 类风湿病学
背景情况:
- 类风湿性关节炎 (RA) 的病因是复杂的,调节性T细胞 (Treg) 功能障碍是可疑的因素.
- 微RNA-21 (miR-21) 呈现出亲骨质细胞原和免疫原性质,这表明它在RA进展中发挥了作用.
研究的目的:
- 研究血miR-21和Treg细胞频率作为RA进展的生物标志物.
- 评估RA患者miR-21和Treg频率之间的关系.
主要方法:
- 60名RA患者根据DAS28-ESR被分为不活跃 (n=30) 和活跃 (n=30) 组.
- 使用流细胞计测量测量了Treg细胞的频率.
- 血miR-21表达水平使用实时定量PCR量化量化.
主要成果:
- 与不活跃的患者相比,活跃的RA患者表现出显著更高的miR-21表达 (p=0.004) 和较低的Treg频率 (p<0.001).
- 特雷格频率与DAS-28-ESR负相关 (r=-0.508,p<0.001),而miR-21折叠变化与正相关 (r=0.334,p<0.009).
- 在miR-21和Treg频率之间没有发现相关性. 在区分活性与非活性RA时,Treg频率显示出比miR-21 (AUC=0.717) 更高的诊断准确性 (AUC=0.907) .
结论:
- 特雷格频率和miR-21水平与RA疾病活性有差异性相关.
- 对Treg频率的下调和对miR-21的上调可以作为RA活动的潜在生物标志物.
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