重新思考暴露于和血压之间的联系
Xue Feng Hu1, Allison Loan1, Hing Man Chan2
1Chemical and Environmental Toxicology Program, Department of Biology, University of Ottawa, 30 Marie Curie, Ottawa, ON, K1N 6N5, Canada.
Archives of toxicology
|January 13, 2025
概括
暴露于与高血压 (高血压) 有关. 这一审查证实了剂量与反应的关系,通过各种生物机制导致高血压,并增加了相关的健康风险.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 心血管疾病流行病学
背景情况:
- 高血压是一种广泛的慢性疾病,具有重大的全球健康影响.
- 环境化学物质,特别是 (Hg),越来越多地被认为是导致高血压的潜在因素.
- 是世界卫生组织确定的全球健康问题,某些人群面临更高的暴露风险.
研究的目的:
- 批判性地审查通过 (有机和无机) 影响高血压的生物机制.
- 更新有关暴露与血压 (BP) 结果之间的联系的证据.
- 用布拉德福德山标准来评估证据的权重.
主要方法:
- 现有文献的系统审查和元分析,包括2018年的出版物.
- 包括16项最近的流行病学研究 (过去5年) 调查暴露和高血压.
- 对对心血管健康的生物学影响和潜在机制的评估.
- 对剂量反应关系和证据强度的评估.
主要成果:
- 动物研究表明,暴露于和血压之间存在强烈的剂量反应关系.
- 有令人信服的证据表明,通过结构性/功能性血管变化,氧化应激和-血管素系统变化导致高血压.
- 最近的流行病学研究证实了暴露与高血压风险之间的积极关联,尽管在较低剂量的效果是混合的,可能会受到其他金属的同时暴露的影响.
结论:
- 通过多种生物途径,有机和无机的暴露与高血压密切相关.
- 证据支持在高血压的发展中的作用,即使在较低的暴露水平上,当同时暴露时也会发生.
- 建议头发含量为2μg/g作为公共卫生监管的切断值,特别是对于成年人.
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