预孕和怀孕早期暴露于细颗粒物和神经系统异常之间的关联:一个嵌套的病例控制研究
Bao-Ru Chuang1, Chung-Chin Lee1, Yu-Ting Lin2,3
1Department of Occupational Safety and Health, College of Public Health, China Medical University, No. 100, Section 1, Economic and Trade Road, Beitun District, Taichung, 406040, Taiwan, Republic of China.
European journal of epidemiology
|January 13, 2025
概括
在怀孕前和早期暴露于细颗粒物 (PM2.5) 增加了后代神经系统异常的风险. 这包括神经管缺陷,如无脑症和脑,突出了关键的暴露窗口.
科学领域:
- 环境健康 环境健康
- 生殖流行病学 生殖流行病学
- 发展性毒理学 发展性毒理学
背景情况:
- 环境因素与神经系统异常有关.
- 细颗粒物 (PM2.5) 对这些异常的特定影响需要进一步阐明.
- 了解妊娠前期和早期怀孕期间的临界暴露期至关重要.
研究的目的:
- 调查PM2.5暴露与神经系统异常之间的关联.
- 为了确定与PM2.5.5相关的特定神经管缺陷表型.
- 为了确定PM2.5暴露在怀孕前和怀孕初期的关键时间窗口.
主要方法:
- 一项嵌套病例对照研究利用了台湾母亲和儿童健康数据库 (2004-2017年).
- 基于卫星的模型估计了从怀孕前13周到怀孕8周的每周平均PM2.5度 (1公里分辨率).
- 使用分布式滞后非线性模型 (DLNMs) 的条件后勤回归分析了暴露-反应关系.
主要成果:
- 增加10μg/m3的PM2.5与神经系统异常 (aOR: 1.21) 和脑 (aOR: 1.56) 的更高风险有关.
- 无脑症风险与怀孕前13周的PM2.5暴露有关 (aOR: 1.48).
- 从怀孕前8至11周到怀孕1至8周,DLNM每周都显示出高风险.
结论:
- 在怀孕前和怀孕初期暴露于PM2.5与子女神经系统异常的风险增加有关.
- 神经管缺陷,包括无脑症和脑,特别与PM2.5暴露有关.
- 这些发现强调了在早期发育的关键窗口期间减轻PM2.5暴露的重要性.
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