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肺功能障碍在患有骨质疏松症的儿童:一个横截面研究
Ankit Kumar Meena1, Gautam Kamila1, Vaishak Anand1
1Centre of Excellence and Advanced Research for Childhood Neurodevelopmental Disorders, Child Neurology Division, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
几乎一半的患有这种疾病的儿童经历了肺功能受损,甚至在疾病的早期. 这种肺功能障碍与运动功能和特定的遗传缺失有关,强调了早期监测的必要性.
科学领域:
- 儿科肺病学 儿科肺病学
- 神经肌肉疾病 神经肌肉疾病
- 遗传学 是一个遗传学.
背景情况:
- 肌肉发育不良症,包括杜恩肌肉发育不良症 (DMD),影响肌肉力量,并可能影响呼吸功能.
- 肺部并发症是DMD患者患病和死亡的主要原因.
- 了解肺功能障碍的流行和进展对于及时干预至关重要.
研究的目的:
- 为了确定5-18岁儿童肺功能障碍的患病率.
- 调查肺功能障碍参数与运动功能之间的相关性.
- 为了确定与肺部参与相关的潜在遗传因素.
主要方法:
- 通过肺功能测试 (PFT) 和六分钟步行测试 (6MWT) 评估了133名确诊的DMD儿童.
- 用维格诺斯和布鲁克尺度评估功能性肌肉力量.
- 定义的肺功能障碍为<80%预测的强迫生命能力 (FVC).
主要成果:
- 肺功能障碍的总体患病率为48.12%.
- 患病率因年龄组而异,10-18岁年龄组的患病率最高 (57.78%).
- 在预测的FVC和运动功能参数 (6MWT,Vignos,Brooke分数) 和特定的遗传删除 (R17,18,19谱状重复) 之间发现了显著的关联.
结论:
- 肺功能障碍在患有肌痛性肌痛病的儿童中很普遍,在疾病的早期过程中出现.
- 肺功能障碍的患病率在早期和长期疾病阶段是相似的.
- 这些研究结果强调了早期和持续的呼吸系统监测在儿科肌病的重要性.
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