以免疫检查点抑制剂为次要的喷发性角质腺瘤:叙事性综述
Layna Mager1, Jose A Plaza2,3, Jennifer Sopkovich2
1The Ohio State University College of Medicine, Columbus, OH, USA.
Archives of dermatological research
|January 13, 2025
概括
喷发性角瘤 (KA) 是癌症免疫疗法的罕见副作用. 氨或甲醇的内射注射有效地治疗了这些病变,提供了比手术更少的侵入性选择.
科学领域:
- 皮肤病学 皮肤病学
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 癌症免疫疗法,特别是免疫检查点抑制剂,越来越多地用于晚期恶性瘤.
- 皮肤不良事件是常见的,但更罕见的效应,如喷发性角瘤 (KA) 的理解较少.
- 手术切除是KA的标准治疗方法,但人们正在寻求更少的侵入性选择.
研究的目的:
- 为了研究内伤注射用于治疗突发性角瘤 (KA) 的疗效,其次是免疫检查点抑制剂治疗.
- 审查现有的文献,并介绍关于这种特定不良事件的新案例数据.
主要方法:
- 在PubMed数据库中搜索了与免疫检查点抑制剂相关的爆发性KA病例.
- 另外还包括了来自作者机构的三个未发表的案例.
- 分析了患者对治疗方式和结果的数据.
主要成果:
- 确定了19名免疫疗法诱导的喷发性KA患者 (平均年龄为78.9岁).
- 治疗包括内伤注射 (n=7),全身药物 (n=5),或替代疗法 (n=7).
- 观察到总体改善率为89.5%,在接受内三氨或甲醇的患者中完全消失.
结论:
- 内注射是免疫治疗引起的喷发性角瘤的潜在有效和不那么侵入性治疗方法.
- 这种方法可能允许继续或重新启动关键的癌症免疫疗法.
- 对治疗免疫相关不良事件的内伤疗法的进一步研究是有必要的.
关键词:
皮肤不良影响 皮肤不良影响爆发性角质腺瘤 (Keratoacanthoma) 是一种爆发性角质腺瘤.一般皮肤病学 皮肤病学免疫检查点抑制剂 免疫检查点抑制剂免疫治疗是一种免疫疗法.支持性皮肤瘤学更多相关视频
09:56A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy
Published on: February 21, 2025
453
07:29Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
11.4K
相关概念视频
01:27Tumor Immunotherapy
469
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
469
01:30Skin Cancer
3.1K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
3.1K
01:19Clinical Applications of Epidermal Stem Cells
2.7K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.7K