冠状动脉化进展和系统性红斑狼患者的参与:一个纵向队列研究
Lise Zinglersen1, Amanda Hempel Zinglersen2, Katrine Aagaard Myhr3
1Copenhagen Research Center for Autoimmune Connective Tissue Diseases (COPEACT), Copenhagen University Hospital, Rigshospitalet, Denmark. Lise.zinglersen.01@regionh.dk.
Rheumatology international
|January 13, 2025
概括
在全身性红斑狼 (SLE) 患者中,冠状动脉化 (CAC) 的进展与吸烟,更长的疾病持续时间和现有的CAC有关. 在这项研究中,功能和心肌梗塞发病率显示出不确定的关联.
科学领域:
- 心脏病学 心脏病学
- 类风湿病学 类风湿病学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 系统性红斑狼 (SLE) 与加速的心血管疾病有关.
- 冠状动脉化 (CAC) 是动脉样硬化和心血管风险的标志物.
- 了解影响SLE中CAC进展的因素对于风险分层至关重要.
研究的目的:
- 为了确定SLE患者的CAC进展是否与传统的心血管风险因素,功能和心肌梗塞 (MI) 发生率有关.
- 在SLE队列中确定CAC进展的预测因子.
主要方法:
- 在99名SLE患者中,使用心脏计算机断层扫描 (CT) 在5年内对CAC进展的前性评估.
- 多变量波桑回归分析,以评估CAC进展与基线因素之间的关联,包括心血管风险因素,SLE疾病持续时间,狼性炎和估计的淋巴细胞过率 (eGFR).
- 在随访期间分析MI发病率.
主要成果:
- 在5年内,CAC进展发生在39%的SLE患者中.
- CAC进展与一直吸烟 (RR1.69),较长的SLE疾病持续时间 (每年RR1.03) 和基线CAC存在 (RR2.52) 有显著关联.
- 与脏干扰 (eGFR类别) 和心脏病发病率的关联是不确定的.
结论:
- 吸烟,较长的SLE持续时间和基线CAC预测SLE患者的CAC进展.
- 这项研究没有在这个队列中确定CAC进展与功能或MI发病率之间的明确关联.
- 需要进一步的研究来澄清因子和心脏病发作风险在SLE患者中CAC进展中的作用.
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