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化疗相关的认知障碍和神经网络动态的变化:系统性审查
Sandra Leskinen1, Samir Alsalek2, Rosivel Galvez3
1State University of New York Downstate Medical Center, Brooklyn, NY.
Neurology
|January 13, 2025
概括
化疗可能会改变大脑连接,并导致癌症患者的认知障碍. 然而,目前的证据是不一致的,需要进一步的研究来得出最终的结论和干预措施.
科学领域:
- 神经科学是一个神经科学.
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
背景情况:
- 化疗 (CTX) 与化疗相关的认知障碍 (CRCI) 有关.
- 了解CTX对大脑结构和功能的影响对于治疗癌症患者的CRCI至关重要.
研究的目的:
- 系统地审查和综合现有关于CTX与非中枢神经系统癌症患者大脑变化 (功能和结构) 之间的关系的文献.
- 评估这些大脑变化与CRCI之间的关联.
主要方法:
- 在PubMed/MEDLINE,Web of Science和Embase数据库中进行了全面的文献搜索.
- 包括63项涉及3642名患者的研究,分析神经成像技术 (fMRI,DTI),认知评估和结构/功能连接 (FC) 变化.
- 研究质量使用纽卡斯尔-太华尺度 (NOS) 进行评估.
主要成果:
- 许多研究报告了CTX后关键大脑网络的结构和FC变化.
- 经常报告认知缺陷,包括学习,记忆,处理速度和注意力受损.
- 虽然72%的研究发现了连接性变化和认知衰退之间的相关性,但高证据研究往往没有显示出任何显著的关联.
结论:
- 有证据表明CTX可以影响大脑连接和神经动态,可能导致认知困难.
- 目前的发现是不一致的,低证据研究显示的关联比高证据研究更频繁.
- 需要更强大的标准化研究来证实这些影响,并为CRCI开发干预措施.
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