在炎症性肠病中缺铁和疲劳:系统性审查
Stephanie Sartain1, Maryam Al-Ezairej2, Martin McDonnell1
1Department of Gastroenterology, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom.
PloS one
|January 13, 2025
概括
缺铁,带有或没有贫血,可能会增加炎症性肠病 (IBD) 患者的疲劳. 补铁可以帮助那些患有IBD和铁缺乏症的人管理疲劳.
科学领域:
- 胃肠病学 胃肠病学
- 血液学 血液学 血液学
- 临床医学 临床医学
背景情况:
- 疲劳是患有炎症性肠病 (IBD) 的个体普遍和具有挑战性的症状.
- 铁缺乏症 (ID),有或没有贫血,对IBD疲劳的具体影响尚不清楚.
- 了解这种关系可能会提高IBD患者的疲劳管理策略.
研究的目的:
- 系统地审查有关铁缺乏 (带有或没有贫血) 与IBD患者疲劳之间的联系的现有证据.
- 综合结合有关铁状况在IBD个体疲劳经验中的作用的发现.
主要方法:
- 在多个数据库 (MEDLINE,OVID,CINAHL,Web of Science) 中进行了系统的文献搜索.
- 纳入标准侧重于研究测量IBD患者的铁状况和患者报告的疲劳结果.
- 偏差评估使用了纽卡斯尔太华尺度,研究根据缺铁定义 (有或没有贫血) 进行分组.
主要成果:
- 包括7项涉及1425名参与者的研究,但显著的方法差异阻止了定量合成.
- 两项研究将缺铁而没有贫血 (IDWA) 与非缺铁状态进行比较,发现IDWA组的疲劳得分较低.
- 检查铁缺乏不论贫血的研究报告混合的结果,只有一个表明更高的疲劳患病率.
结论:
- 在研究IBD中铁缺乏和疲劳的研究中存在明显的异质性.
- 一些证据表明,在没有贫血 (IDWA) 的铁缺乏症患者中,疲劳水平略有增加.
- 铁替代疗法需要考虑改善铁缺乏IBD患者的疲劳.
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