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Updated: Jun 2, 2025

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chikungunya 病毒 nsP4 中的突变降低了病毒适应性和对宽谱抗病毒4'-Fluorouridine 的敏感性.

Peiqi Yin1, Elizabeth B Sobolik2, Nicholas A May3

  • 1Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, United States of America.

PLoS pathogens
|January 13, 2025
PubMed
概括

抗病毒药物4'-尿素 (4'-FlU) 对抗奇孔古尼亚病毒 (CHIKV) 是有前途的. 发现了抗药性突变,但不影响CHIKV复制,支持4'-FlU.

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Viral Mutations00:36

Viral Mutations

A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
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