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由POPs诱导的SIRT6改变对肠粘膜屏障功能的影响:综合性审查

Guangcan Chen¹, Tengyang Huang¹, Yifeng Dai²

¹Laboratory of Environmental Medicine and Developmental Toxicology, Shantou University Medical College, Shantou, Guangdong 515041, China; Department of Digestive Surgery, the First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515000, China.

Ecotoxicology and environmental safety

|January 13, 2025

概括

持久性有机污染物 (POP) 损害了肠道屏障的功能. 本综述探讨了POPs如何影响肠道以及Sirtuin 6 (SIRT6) 在这个过程中的作用,并提出了治疗途径.

科学领域:

环境健康环境健康
胃肠病学胃肠病学
分子生物学分子生物学

背景情况:

持久有机污染物 (POP) 是广泛存在的环境污染物,已知对健康有不良影响.
肠道粘膜屏障对肠道健康至关重要,它可以保护我们免受病原体的侵害,并维持平衡.
赛尔图因6 (SIRT6) 是一种关键蛋白质,参与细胞稳定,炎症和新陈代谢.

研究的目的:

审查 POPs 对肠道屏障功能的影响.
阐明 POPs 破坏肠道屏障的机制.
探索SIRT6在POP引起的肠损伤中的作用及其治疗潜力.

主要方法:

关于POPs,肠道屏障和SIRT6研究的文献综述.
对拟议的分子和细胞机制的分析.
综合当前的研究成果和识别知识差距.

主要成果:

污染物通过细胞损伤,表观遗传变化,炎症,微生物群变化和代谢干扰与肠道疾病有关.
虽然已有证据证明了POPs对肠道屏障的影响,但涉及SIRT6的具体机制尚未完全理解.
SIRT6在调节肠道屏障完整性相关的细胞过程中发挥作用.

结论:

通过破坏肠道屏障,POPs对肠道健康构成重大威胁.
需要进一步的研究来澄清POPs,SIRT6和肠道健康之间的复杂关系.
向SIRT6可能为POP诱导的肠功能障碍提供一种新的治疗策略.

关键词:

表观遗传修饰是一种表观遗传修饰.炎症反应炎症反应肠道微生物组是什么意思依赖NAD (((+) 的脱乙酶.暴露于污染物的暴露.

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