口服的obeldesivir在非人类灵长类动物中提供了对马尔堡病毒的暴露后保护
Robert W Cross1,2, Courtney Woolsey1,2, Abhishek N Prasad1,2
1Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.
Nature medicine
|January 13, 2025
概括
口服药物obeldesivir (ODV) 在保护马尔堡病毒 (MARV) 感染方面表现有前途. 一个为期10天的ODV疗法在中提供了80%的保护,突出了其作为可访问治疗的潜力.
科学领域:
- 病毒学 病毒学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 马尔堡病毒 (MARV) 构成了严重的公共卫生威胁,死亡率高 (高达90%).
- 目前还没有批准的疫苗或治疗MARV感染.
- 有效的暴露后预防对于控制filovirus疫情至关重要.
研究的目的:
- 为了评估口服核糖类模拟前药物奥贝尔德西维尔 (ODV) 对MARV感染的疗效.
- 在非人类灵长类动物模型中评估ODV作为暴露后预防的保护潜力.
主要方法:
- (Cynomolgus macaques) (n=6) 接受了为期10天的每日一次ODV治疗方案,从暴露于致命的MARV挑战后的24小时开始.
- 监测了保护率,病毒复制率,疾病发病率和生存率.
- 进行了转录组分析,以确定与成功结果相关的宿主反应.
主要成果:
- 这种ODV疗法提供了80%的保护,免受一千倍致命的MARV挑战.
- 在受保护的动物中,ODV治疗延迟了病毒复制和疾病发病.
- 早期适应性免疫反应与成功的结果相关.
结论:
- 奥贝尔德西维尔在体内对MARV表现出显著的抗病毒活性.
- 口服ODV提供了一个有希望的,在后勤上有利的暴露后预防费洛病毒感染.
- 进一步开发ODV可以为管理MARV疫情提供关键工具.
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