自然来源的多糖对神经疾病的影响:一篇综述
Luyuan Yang1, Hailu Hou1, Liping Lu2
1Key Laboratory for Information System of Mountainous Areas and Protection of Ecological Environment, Guizhou Normal University, Guiyang 550001, China; Guizhou Engineering Laboratory for Quality Control & Evaluation Technology of Medicine, Guizhou Normal University, Guiyang 550001, China.
International journal of biological macromolecules
|January 13, 2025
概括
自然来源的多糖体 (NSP) 显示出治疗神经系统疾病 (NDs) 的前景,因为它们的毒性低和独特的生物活性. 本综述探讨了它们的潜在机制和NDs的治疗应用.
科学领域:
- 药理学 药理学是指药理学的学科.
- 神经科学是一个神经科学.
- 自然产品 化学 化学
背景情况:
- 神经系统疾病 (NDs) 在全球范围内正在增加,造成严重的健康和经济负担.
- 目前对ND的治疗方法通常涉及具有显著副作用和高成本的化学药物.
- 迫切需要更温和,有效的治疗药物用于NDs.
研究的目的:
- 系统地审查自然来源多糖体 (NSP) 在缓解NDs中的药理学活性.
- 探索NSP治疗效果的潜在分子机制.
- 确定当前研究的局限性,并建议基于NSP的NDs疗法的未来方向.
主要方法:
- 系统性文献审查,重点关注NSP及其对神经疾病的影响.
- 药理学活动的分析,包括抗炎,抗氧化,抗亡,自调节,神经保护和镇静-催眠.
- 对分子机制的评估和研究局限性的讨论.
主要成果:
- 国家药物供应商表现出与NDs治疗相关的多种药理学活动.
- 潜在的机制包括对炎症的调节,氧化应激,亡和自.
- NSPs显示神经保护和镇静催眠效应.
结论:
- NSPs代表了一个有前途的自然化合物类别,用于开发用于NDs的新疗法剂.
- 需要进一步的研究来阐明机制和优化治疗策略.
- 本综述为推进基于NSP的神经系统疾病治疗方法提供了科学基础.
相关概念视频
Parkinson's Disease: Overview
463
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
463
Neural Regulation
39.1K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.1K
Disorders of the Nervous Tissue
1.1K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises...
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises...
1.1K
Lysosomal Hydrolases
3.7K
Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
3.7K


