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Updated: Jun 2, 2025

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

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阳性MCM6-c-Myc反循环调解了膀癌的进展和对西斯普拉丁的耐药性

Jirong Wang1, Xiaoran Li2, Liwei Zhao2

  • 1Department of Urology, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China; Gansu Province Clinical Research Center for Urinary System Disease, Lanzhou, China; Cuiying Biomedical Research Center, Lanzhou University Second Hospital.

International journal of biological macromolecules
|January 13, 2025
PubMed
概括

迷你染色体维护6 (MCM6) 通过增强DNA损伤修复,驱动膀癌 (BLCA) 的化学抵抗. 向MCM6可能会克服BLCA患者的西斯普拉丁耐药性.

关键词:
西斯普拉丁的耐药性修复DNA损伤的修复在MCM6-c-Myc正反循环中.

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