[确定Jianwei Xiaoshi颗粒的物理性质和对离散元素模拟参数的校准]
Zi-Qian Wang1, Fan Wu2, Zhi-Jian Zhong3
1Key Laboratory of Modern Preparations of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine Nanchang 330004, China Jiangxi Drug Inspection Center Nanchang 330000, China.
概括
这项研究使用响应表面方法对Jianwei Xiaoshi Granules的离散元素模型参数进行了校准. 优化的参数准确预测颗粒的动态行为,确保可靠的模拟制药应用.
科学领域:
- 制药工程 制药工程
- 材料科学 材料科学 材料科学
- 计算建模 计算建模
背景情况:
- 准确的离散元件建模Jianwei Xiaoshi颗粒对于理解平板电脑配方动态至关重要.
- 现有的模型缺乏精确的参数设置,影响模拟可靠性.
- 校准是必要的,以提高颗粒-颗粒相互作用的准确性.
研究的目的:
- 为 Jianwei Xiaoshi 颗粒优化和校准离散元素模型参数.
- 为了提高动态响应特性模拟的准确性.
- 建立一个可靠的模拟模型,用于制药颗粒的行为.
主要方法:
- 利用响应表面方法来优化基于静止角度的离散元素参数.
- 在EDEM软件中使用了Hertz-Mindlin与Johnson-Kendall-Roberts (JKR) V2模型.
- 进行了普莱克特-伯曼和最的登实验,用于参数选和范围确定.
- 使用Box-Behnken设计建立了二次回归方程.
主要成果:
- 确定了颗粒-颗粒静态摩擦系数,颗粒-颗粒滚动摩擦和颗粒-钢板滚动摩擦作为重要参数.
- 确定了最佳参数组合:0.330 (颗粒-颗粒静态摩擦),0.222 (颗粒-颗粒滚动摩擦) 和0.229 (颗粒-钢板滚动摩擦).
- 与物理实验相比,实现了模拟的休息角度,相对误差为0.05%的最小相对误差.
结论:
- 成功校准了 Jianwei Xiaoshi 颗粒的离散元素参数,提高了模拟可靠性.
- 优化的模型准确地预测了休息角度,验证了它的有效性.
- 这项工作为制药颗粒的表征提供了可靠的模拟方法.
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