中性粒细胞对血管壁的粘附会损害COVID-19病理中的肺循环
Hiroshi Ueki1,2, I-Hsuan Wang3, Maki Kiso4
1Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan. h-ueki@ims.u-tokyo.ac.jp.
Nature communications
|January 13, 2025
概括
严重的COVID-19涉及中性粒细胞对肺血管的粘附,导致微血栓和血流受损. 这项研究揭示了中性粒细胞的行为如何导致COVID-19的严重程度和肺 perfusion 缺陷.
科学领域:
- 肺部医学 肺部医学
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
背景情况:
- 微血栓的形成与COVID-19的严重程度相关.
- 这种关联背后的确切机制尚未完全理解.
研究的目的:
- 阐明中性粒细胞粘附和微血栓形成在SARS-CoV-2引起的肺炎中的作用.
- 调查导致COVID-19严重程度的体内机制.
主要方法:
- 在SARS-CoV-2感染引起的严重肺炎的小鼠模型中利用了体内两光子成像系统.
- 分析了来自COVID-19患者外周血液单核细胞的scRNA-seq数据.
主要成果:
- SARS-CoV-2 感染增加了小鼠肺中的血管内中性粒细胞上的粘附分子的表达.
- 长时间的中性粒细胞粘附导致了血小板聚合和肺 perfusion 损害.
- 在重症COVID-19患者的中性粒细胞中观察到CD44和SELL表达的升高,与小鼠模型发现一致.
结论:
- 由中性粒细胞对肺血管的粘附驱动的肺 perfusion 缺陷是 COVID-19 严重性的重要贡献者.
- 中性粒细胞介导的微血栓形成在严重的COVID-19的病理生理学中起着至关重要的作用.
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