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Updated: Jun 2, 2025

Visualizing the Conformational Dynamics of Membrane Receptors Using Single-Molecule FRET
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Published on: August 17, 2022

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在C类GPCR阳性基调节中的合规多样性

Giuseppe Cannone1, Ludovic Berto2, Fanny Malhaire2

  • 1MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK.

Nature communications
|January 13, 2025
PubMed
概括

阳性全调节剂 (PAMs) 通过结合到不同的位点来改变元类谷氨酸受体5 (mGlu5) 的功能,从而影响受体平衡和形状变化. 这揭示了PAMs如何调节mGlu5受体活性,用于潜在的治疗应用.

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