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Xiaoming Liang¹, Yuxia Yuan¹, Junbin Wang¹

¹Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical college, Kunming, China.

|January 13, 2025

概括

新的mRNA疫苗,BSCoV05和BSCoV06,对SARS-CoV-2变种表现出广泛的活性. 这些疫苗产生了强大的免疫反应,并保护小鼠免受EG.5.1菌株的感染,这表明未来可能会有变种保护.

科学领域:

病毒学病毒学
免疫学免疫学免疫学
疫苗学疫苗学疫苗学

背景情况:

有突变的SARS-CoV-2变种可以逃避疫苗,需要新的疫苗策略.
现有疫苗对新兴变种的疗效较低,这凸显了需要广泛的保护.

研究的目的:

设计和评估具有针对SARS-CoV-2变种增强的广泛抗病毒活性的新型mRNA疫苗 (BSCoV05,BSCoV06).
在小鼠模型中研究这些新疫苗的免疫性和保护效果.

主要方法:

将点突变引入原始SARS-CoV-2菌株的受体结合域 (RBD),以创建BSCoV05和BSCoV06mRNA疫苗.
在BALB/c和K18-hACE2小鼠中测试了疫苗,以评估免疫反应,包括抗体产生和细胞免疫力.
用EG.5.1菌株挑战小鼠,以评估疫苗诱导的保护.

主要成果:

BSCoV05和BSCoV06引起了强大的免疫反应,包括高水平的针对BA.2 RBD的特定结合抗体.
这两种疫苗都诱导了针对广泛的SARS-CoV-2变体的中和抗体,包括Alpha,Beta,Omicron (BA.1,BA.2,BA.5,XBB.1.5,XBB.1.16),以及EG.5.1亚系.
BSCoV06表现出更广泛的中和抗体活性,两种疫苗都提供了对小鼠EG.5.1菌株挑战的保护.

结论:

开发的mRNA疫苗,BSCoV05和BSCoV06,对SARS-CoV-2变种表现出有希望的广谱活性.
这种疫苗设计策略需要在非人类灵长类动物中进行进一步的研究,以对未来的变种进行潜在的应用.
这项研究为开发下一代疫苗提供了有价值的见解,以有效控制SARS-CoV-2的演变.

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