自由脂肪酸受体4通过肠道微生物群调节饮食糖的偏好
Tingting Zhang1,2,3, Wei Wang1,4, Jiayu Li1,2,3
1Wuxi School of Medicine, Jiangnan University, Wuxi, China.
Nature microbiology
|January 13, 2025
概括
降低糖尿病中自由脂肪酸受体4 (Ffar4) 表达与增加的糖摄入量有关. 肠道细菌的代谢物潘托酸受Ffar4的影响,通过GLP-1和FGF21信号调节糖偏好.
科学领域:
- 代谢和内分泌学
- 肠道微生物组研究研究
- 营养神经科学 营养神经科学
背景情况:
- 过度食用糖会导致糖尿病发病率上升.
- 导致糖偏好的确切机制尚不清楚.
- 自由脂肪酸受体4 (Ffar4) 表达在糖尿病中减少,并与高糖摄入量有关.
研究的目的:
- 阐明肠道Ffar4在调节糖偏好中的作用.
- 研究连接Ffar4,肠道微生物和糖摄入中的代谢信号的分子通路.
主要方法:
- 在糖尿病患者和小鼠模型中分析Ffar4表达.
- 在小鼠中遗传删除肠道Ffar4,以评估对肠道微生物群和行为的影响.
- 测量肠道微生物组成,代谢物水平 (泛多酸盐) 和激素分泌 (GLP-1,FGF21).
主要成果:
- 在小鼠中,肠道Ffar4删除导致Bacteroides vulgatus和泛酸盐的减少.
- 减少的泛多酸盐水平与增加的饮食糖偏好相关.
- 潘托酸刺激了GLP-1分泌,通过肝脏FGF21释放抑制了糖偏好.
结论:
- 在消极调节糖偏好方面,Ffar4起着至关重要的作用.
- 肠道细菌B. vulgatus及其代谢物潘托酸是这一途径的关键媒介.
- 针对B. vulgatus-pantothenate轴提供了一个潜在的治疗策略,通过糖偏好调节来管理糖尿病.
更多相关视频
10:29Measuring Oral Fatty Acid Thresholds, Fat Perception, Fatty Food Liking, and Papillae Density in Humans
Published on: June 4, 2014
20.2K
08:07Simultaneous Detection of c-Fos Activation from Mesolimbic and Mesocortical Dopamine Reward Sites Following Naive Sugar and Fat Ingestion in Rats
Published on: August 24, 2016
9.0K
相关概念视频
Regulation of Food Intake
185
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
185
Lipid Digestion
90.6K
Lipids are large molecules that are generally not water-soluble. Since most of the digestive enzymes in the human body are water-based, there are specific steps the body must take to break down lipids and make them available for use.
90.6K
Hormonal Regulation
43.1K
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
43.1K
Gustation
47.6K
Gustation is a chemical sense that, along with olfaction (smell), contributes to our perception of taste. It starts with the activation of receptors by chemical compounds (tastants) dissolved in the saliva. The saliva and filiform papillae on the tongue distribute the tastants and increase their exposure to the taste receptors.
47.6K
Glucose Absorption Into the Small Intestine
31.3K
Complex carbohydrates consumed cannot be absorbed into the small intestine in their original form. First, they must be hydrolyzed to a monosaccharide form such as glucose or galactose. These monosaccharides are then transported across the intestinal membrane and into the blood via transcellular transport. The intestinal epithelial cells allow the movement of these monosaccharides with a defined 'entry' through membrane transporter proteins present on their apical membrane and...
31.3K
Feedback Loops
55.8K
In most cases, excessive hormone production is prevented by negative feedback—a loop that starts with a stimulus inducing the release of a particular substance, like a hormone, to maintain a certain level before triggering a signal that results in a decrease in further release of the hormone.
55.8K
