纵向血清蛋白质组映射揭示了健康衰老和相关心脏代谢疾病的生物标志物
Jun Tang1, Liang Yue1, Ying Xu2,3
1Westlake Center for Intelligent Proteomics, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.
Nature metabolism
|January 13, 2025
概括
研究人员确定了86种与衰老和慢性疾病有关的血液蛋白质. 一个新的蛋白质组健康衰老评分 (PHAS) 预测疾病风险,并且可以受到肠道微生物群的影响.
科学领域:
- 生物化学 生物化学
- 老年学是指老年学的学科.
- 基因组学就是基因组学.
背景情况:
- 血液蛋白质组为衰老和相关疾病提供了潜在的生物标志物.
- 这些生物标志物的纵向验证往往缺乏.
研究的目的:
- 在中年和老年人中纵向地图化血液蛋白质组.
- 为了确定与衰老,临床特征和慢性病发病率相关的蛋白质.
- 开发健康衰老的预测得分,并确定影响因素.
主要方法:
- 分析了来自3,796个人的7,565个血清样本,跨越了9年的三个时间点.
- 鉴定了86种与衰老相关的蛋白质及其与32种临床特征和14种疾病的关联.
- 开发一种机器学习模型,使用22种蛋白质创建蛋白质健康衰老得分 (PHAS).
- 研究肠道微生物群对PHAS的影响.
主要成果:
- 确定了86种与衰老相关的蛋白质,与32种临床特征和14种主要与年龄相关的慢性疾病有关.
- 使用22种蛋白质开发了一个蛋白质健康衰老评分 (PHAS),证明了对心脏代谢疾病发病率的预测能力.
- 肠道微生物群被确定为影响PHAS的可修改因素.
结论:
- 这项研究为了解衰老和心脏代谢疾病中的血清蛋白提供了宝贵的资源.
- PHAS提供了一种用于预测健康衰老和疾病风险的新工具.
- 这些发现表明,促进健康衰老和干预与年龄相关的疾病是潜在的治疗目标.
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