Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Epigenetic Regulation01:46

Epigenetic Regulation

30.9K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
30.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Meta-analysis of DNA methylation aging signatures in 17 human tissues.

Nature aging·2026
Same author

Correction to: Searching for shared epigenetic clocks: evaluating ultra‑conserved markers in a de novo genome assembly of the albacore tuna.

GeroScience·2026
Same author

Searching for shared epigenetic clocks: evaluating ultra-conserved markers in a de novo genome assembly of the albacore tuna.

GeroScience·2026
Same author

Longitudinal changes in epigenetic clocks predict survival in the InCHIANTI cohort.

Nature aging·2026
Same author

Epigenetic Clocks of Biological Aging and Risk of Incident Mild Cognitive Impairment and Dementia: The Women's Health Initiative Memory Study.

Aging cell·2026
Same author

Guidelines on optimizing DNA methylation reference panels for cell-type deconvolution.

Communications biology·2026
Same journal

Genetic origins and constraints of evolutionary innovation.

Nature reviews. Genetics·2026
Same journal

Single-cell four-omics with CHARM.

Nature reviews. Genetics·2026
Same journal

Molecular integration of seasonal temperature signals in flowering time control.

Nature reviews. Genetics·2026
Same journal

RBPscan measures protein-RNA interactions in living cells.

Nature reviews. Genetics·2026
Same journal

Revisiting retinal and macular degeneration in the genomics era.

Nature reviews. Genetics·2026
Same journal

How evolution builds three morphs from one genome.

Nature reviews. Genetics·2026
查看所有相关文章

相关实验视频

Updated: Jun 2, 2025

Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine
08:53

Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine

Published on: January 26, 2024

964

表观遗传衰老时钟:统计方法和新兴的计算挑战

Andrew E Teschendorff1, Steve Horvath2

  • 1CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China. andrew@sinh.ac.cn.

Nature reviews. Genetics
|January 13, 2025
PubMed
概括
此摘要是机器生成的。

表观遗传钟可以估计年龄和干预效率,但面临着计算方面的挑战. 本综述为构建更好的表观遗传时钟提供了指导方针,用于细胞类型和单细胞分析.

更多相关视频

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
10:39

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

6.2K
Combining Magnetic Sorting of Mother Cells and Fluctuation Tests to Analyze Genome Instability During Mitotic Cell Aging in Saccharomyces cerevisiae
11:08

Combining Magnetic Sorting of Mother Cells and Fluctuation Tests to Analyze Genome Instability During Mitotic Cell Aging in Saccharomyces cerevisiae

Published on: October 16, 2014

12.5K

相关实验视频

Last Updated: Jun 2, 2025

Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine
08:53

Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine

Published on: January 26, 2024

964
A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
10:39

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

6.2K
Combining Magnetic Sorting of Mother Cells and Fluctuation Tests to Analyze Genome Instability During Mitotic Cell Aging in Saccharomyces cerevisiae
11:08

Combining Magnetic Sorting of Mother Cells and Fluctuation Tests to Analyze Genome Instability During Mitotic Cell Aging in Saccharomyces cerevisiae

Published on: October 16, 2014

12.5K

科学领域:

  • 生物技术是生物技术.
  • 计算生物学 计算生物学
  • 老年学是指老年学的学科.

背景情况:

  • 表观遗传钟是机器学习工具,可以估计时间和生物年龄.
  • 它们用于评估抗衰老,细胞再生和疾病预防干预措施.
  • 由于计算和统计方面的挑战,目前对理解,解释和应用这些时钟存在局限性.

研究的目的:

  • 审查表观遗传时钟开发和应用中的计算挑战.
  • 专注于解释,细胞类型异质性和单细胞方法.
  • 为构建可解释的表观遗传钟在细胞和单细胞分辨率提供指导方针.

主要方法:

  • 在表观遗传钟中的计算和统计挑战的文献综述.
  • 在表观遗传时钟模型中分析解释问题.
  • 检查细胞类型异质性及其对时钟精度的影响.
  • 审查新兴的单细胞表观遗传钟方法.

主要成果:

  • 确定了阻碍表观遗传时钟应用的重大计算和统计障碍.
  • 突出了解释表观遗传时钟输出的挑战.
  • 讨论了细胞类型异质性对时钟精度的影响.
  • 审查了单细胞表观遗传钟方法的进展.

结论:

  • 解决计算挑战对于推进表观遗传时钟技术至关重要.
  • 为开发更易解释的表观遗传钟提出了指导方针.
  • 未来的方向包括为细胞类型和单细胞分辨率改进时钟.