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在患有恶性消化系统新生瘤的患者中F-FAPI-42 PET/CT和F-FDG PET/CT:一项对比性对比研究

Min Xiong¹, HongJi You¹, Jingmin Feng¹

¹Department of Nuclear Medicine, the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510260, China.

Molecular imaging and biology

|January 13, 2025

概括

与F-FDG PET/CT相比,F-FAPI-42 PET/CT在消化系统癌症的诊断准确度更高. 这种新型的标志物可以改善病变检测,并影响恶性瘤患者的治疗决策.

科学领域:

在瘤学瘤学.
放射学放射学是一门学科.
核医学就是核医学.

背景情况:

纤维细胞激活蛋白 (FAP) 是一种在各种癌症中过度表达的跨膜蛋白酶.
标有放射性核素的纤维细胞激活蛋白抑制剂 (FAPI) 正成为有前途的瘤成像剂.
F-FDG PET/CT是一种标准的成像方式,但在某些胃肠道恶性瘤中存在局限性.

研究的目的:

为了比较F-FAPI-42 PET/CT与F-FDG PET/CT在患有恶性消化系统瘤的患者的诊断性能.
在初级和转移性部位评估标记物吸收和病变可视化.
确定F-FAPI-42 PET/CT在患者管理中的潜在临床益处.

主要方法:

同时F-FAPI-42 PET/CT和F-FDG PET/CT在42名消化系统瘤患者中进行.
定量分析包括标准化吸收值 (SUV),瘤与肝脏比率 (TLR) 和瘤与血液池比率 (TBR).
两个独立的读者评估了损伤数量和位置;使用科恩的卡帕计算了观察者之间的一致性.

主要成果:

¹⁸F-FAPI-42 PET/CT显示了比¹⁸F-FDG PET/CT更高的吸收率和更好的瘤背景对比度.
对F-FAPI-42 PET/CT的诊断准确度在95.24%至100%之间,超过了F-FDG PET/CT.
通过F-FAPI-42 PET/CT可视化了额外的病变,特别是肝脏和腹转移.
根据F-FAPI-42的PET/CT发现,40.48%的患者改变了治疗策略,而F-FDG的PET/CT发现为4.8%.

结论:

F-FAPI-42 PET/CT 是评估初级消化系统瘤和转移的一个有价值的工具.
与F-FDG PET/CT相比,它提供了优越的病变可视化和诊断准确性.
F-FAPI-42 PET/CT 有助于分期,重新分期和治疗决策,可能指导FAP向治疗或免疫治疗.

关键词:

在18F-FAPI-42中使用.在18F-FDG中.消化系统的新生瘤.纤维细胞激活蛋白质的激活蛋白质聚乙烯/聚乙烯/聚乙烯

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