肠道微生物群变化与肝硬化之间的关联:系统性审查和元分析
Ye Liu1,2,3, Ziwei Chen2, Chang Li1,2
1Beijing Hospital, Peking University Fifth School of Clinical Medicine, National Center of Gerontology, Beijing, China.
BMC gastroenterology
|January 13, 2025
概括
肝硬化患者的肠道微生物组丰富性和多样性减少. 关键的细菌群体,如拉克诺斯皮拉属和鲁米诺可可属,减少,而肠杆菌属和链杆菌属增加,表明显著的肠道失调.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 转基因组学是指转基因组学.
背景情况:
- 肠道微生物群和肝硬化之间的关系是复杂的,发现是不一致的.
- 了解这些微生物差异对于潜在的治疗点至关重要.
研究的目的:
- 进行元分析,以澄清肝硬化患者的微生物差异.
- 为了识别与肝硬化相关的特定细菌种群.
主要方法:
- 在PubMed,Embase,Web of Science和Cochrane图书馆的系统文献搜索.
- 使用随机效应模型计算肝硬化失生比率 (CDR) 和元分析.
- 进行了子组,敏感性和出版偏差分析.
主要成果:
- 对53项研究 (5076名参与者) 的分析显示,肝硬化患者的肠道微生物组丰富度降低 (Shannon,Chao1,观察到的物种,ACE,PD指数).
- 在超过80%的研究中报告了β多样性的显著差异.
- 在肝硬化患者中观察到的Enterobacteriaceae,Pasteurellaceae,Streptococcaceae,Bacilli和Streptococcus的丰富;Lachnospiraceae,Ruminococcaceae和Clostridia的枯竭.
结论:
- 与健康对照人群相比,肝硬化与肠道微生物群丰富度显著降低有关.
- 特定的肠道微生物变化,包括减少有益的亲属和增加机会性病原体,是肝硬化的特征.
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