BMI轨迹与NAFLD和通过衰老-炎症调解的晚期纤维化有关
Haiyang Peng1, Zhibo Zhao1, Jianping Gong1
1Department of Hepatobiliary Surgery, Second Hospital Affiliated to Chongqing Medical University, Chongqing, P. R. China.
BMC public health
|January 13, 2025
概括
身体质量指数 (BMI) 轨迹的快速增加显着增加了非酒精性脂肪肝疾病 (NAFLD) 和晚期纤维化风险,这些风险是由衰老和炎症介导的,独立于胰岛素抵抗.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢健康 代谢健康
- 肥胖问题研究研究
背景情况:
- 全球肥胖流行病正在推动代谢状况和增加非酒精性脂肪性肝病 (NAFLD) 负担.
- 对于不同生命阶段的身体质量指数 (BMI) 模式如何影响NAFLD发展的理解有限.
- 需要调查BMI轨迹与年龄之间的关系和NAFLD风险.
研究的目的:
- 探索不同体重指数 (BMI) 轨迹与年龄之间的关系,以及非酒精性脂肪肝疾病 (NAFLD) 的风险.
- 为了识别整个生命周期中不同的BMI模式及其与NAFLD和晚期肝纤维化相关.
- 阐明BMI-NAFLD关系中的介导因素,如表型年龄和炎症.
主要方法:
- 隐性类轨迹建模 (LCTM) 用于识别3212名NHANES参与者的BMI轨迹 (2017-2020).
- 应用多项逻辑回归来评估BMI轨迹与NAFLD/晚期纤维化之间的关联.
- 结构方程建模 (SEM) 用于研究表型年龄和C反应蛋白的调解效应.
主要成果:
- 确定了三种BMI轨迹:稳步进展,逐渐增加,迅速上升.
- 快速上升的BMI轨迹与NAFLD (OR=2.21) 和晚期纤维化 (OR=3.04) 的风险增加有显著的相关性.
- 衰老和C-反应蛋白调解了快速上升的BMI和NAFLD/晚期纤维化之间的关联,独立于胰岛素抵抗 (IR).
结论:
- 快速上升的BMI轨迹与更高的NAFLD和晚期纤维化易感性有关,由衰老和炎症介导.
- 维持一生中稳定的BMI对于预防NAFLD至关重要.
- 衰老和炎症可能是连接持续肥胖与NAFLD的独特途径,与胰岛素耐药性分开.
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