混合制阻燃剂对美国成年人阻塞性睡眠呼吸暂停综合征的联合暴露
Junping Liu1, Zhaoyue Liu1, Xinru Liu1
1Department of Social Medicine, School of Health Management, Harbin Medical University, Harbin, 150081, China.
BMC public health
|January 13, 2025
概括
暴露于血清制阻燃剂 (BFRs) 与阻塞性睡眠呼吸暂停综合征 (OSAS) 风险的增加有关. 同时暴露于这些BFRs,特别是 PBB153,表明与OSAS发展有显著的关联.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 睡眠医学 睡眠医学
背景情况:
- 制阻燃剂 (BFR) 是与各种健康问题相关的环境污染物.
- BFRs对阻塞性睡眠呼吸暂停综合征 (OSAS) 的综合影响仍未得到充分研究.
- 了解BFR对OSAS的影响对于公共卫生风险评估至关重要.
研究的目的:
- 调查血清BFR暴露与OSAS风险之间的关联.
- 检查单个和混合BFR对OSAS的影响.
- 为了确定有助于OSAS风险的特定BFR.
主要方法:
- 利用了来自1341名参与者的国家健康和营养检查调查 (NHANES) 数据.
- 分析了七个血清BFRs (PBDE28,PBDE47,PBDE99,PBDE100,PBDE153, PBB153,PBDE209) 和OSAS状态.
- 采用多变量逻辑回归,WQS回归,QGC,BKMR和RCS模型进行综合分析.
主要成果:
- 在血清BFR (PBDE28,PBDE47,PBDE99,PBDE100, PBB153) 和OSAS风险之间观察到正相关性.
- WQS,QGC和BKMR模型始终显示BFRs同时暴露对OSAS的毒性影响.
- 确定PBB153是最有影响力的BFR,与OSAS风险有显著的非线性关系.
结论:
- BFRs的同时暴露对OSAS风险产生不利影响.
- PBB153是与BFR相关的OSAS风险的一个关键因素.
- 建议进行进一步的大规模前性和实验性研究,以验证这些发现.
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