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Updated: Jul 25, 2026

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在乳腺癌患者中表征三级淋巴体结构的相关单细胞图谱

Xiaokai Fan1,2, Daqin Feng1, Donggui Wei1

  • 1Department of Neurosurgery, The First Affiliated Hospital, Guangxi Medical University, Nanning, China.

Cancer cell international
|January 13, 2025
PubMed
概括

乳腺癌中的三级淋巴体结构 (TLS) 影响预后和免疫治疗反应. 这项研究揭示了TLS区域内的细胞动态,确定了巨细胞谱系的变化和影响瘤免疫力的关键细胞相互作用.

关键词:
细胞组件 细胞组件 细胞组件细胞细胞的通信.血统轨迹的发展轨迹三级淋巴体结构的第三级淋巴体结构.

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Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...