在肠道贝希特综合征中特异性血代谢物概况
Cheng-Cheng Hou1,2, Hua-Fang Bao3, Chun-Hui She3
1Department of Rheumatology and Immunology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian, China. m15055308511@163.com.
Orphanet journal of rare diseases
|January 13, 2025
概括
这项研究确定了肠道Behçet的关键血代谢差异.
科学领域:
- 代谢学 代谢学 代谢学
- 生物标志物发现发现
- 胃肠病学 胃肠病学
背景情况:
- 肠道贝切特综合征 (IBS) 呈现出显著的发病率和死亡率.
- 目前缺乏IBS的特定诊断生物标志物.
- 了解代谢变化对于诊断和管理至关重要.
研究的目的:
- 为了研究血代谢概况,将IBS患者与健康对照患者区分开来.
- 为了确定活跃与非活跃IBS的代谢生物标志物.
- 发现IBS的新型诊断和预测生物标志物.
主要方法:
- 血样本的全球非向代谢学分析.
- 在30名IBS患者和20名健康受试者中利用LC/MS分析.
- 统计分析包括p值<0.05,VIP>1和ROC曲线分析.
主要成果:
- 在IBS和健康对照组之间确定了147种差异丰富的代谢物 (DAM).
- 关键的代谢途径涉及:酸代谢,GABAergic突触,不和脂肪酸生物合成.
- 有103种代谢物区分出活性与非活性IBS,与氨酸代谢和神经活性联体受体相互作用有关.
结论:
- 血代谢学揭示了IBS患者和疾病活动的不同概况.
- 酸,酸 (SDA) 和酸 (CA) 显示出作为IBS诊断生物标志物的潜力.
- 1-甲基氨酸 (m1A),基尼平,甲基马龙酸 (MMA) 和甲酸可以作为IBS活动的生物标志物.
相关概念视频
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
315
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
315
Inflammatory Bowel Disease IV: Pharmacological Management
110
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
110
Chronic Bowel Disorders: Introduction
386
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
386
Serum Laboratory Studies, Stool Test, Breath Test
311
Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
311


