在精神分裂症中,Wnt/β-catenin信号通路相关 lncRNAs 的表达研究
Fatemeh Manafzadeh1,2, Behzad Baradaran2, Seyed Gholamreza Noor Azar3
1Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
Annals of general psychiatry
|January 13, 2025
概括
这项研究发现,与Wnt/β-catenin通路相关的特定长非编码RNA (lncRNAs) 在精神分裂症患者中失调. 这些lncRNAs显示出潜力作为精神分裂症的诊断生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 精神分裂症是一种复杂的精神疾病,其机制尚不清楚.
- Wnt/β-catenin信号通路与精神分裂症有关,但相关的长非编码RNAs (lncRNAs) 的作用仍然未被探索.
研究的目的:
- 在精神分裂症患者中研究Wnt/β-catenin相关lncRNAs (CCAT2,SNHG5,PTCSC3,DANCR) 和CTNNB1基因的表达水平.
- 为了比较未使用过药物和接受过药物治疗的精神分裂症患者与健康对照者的基因表达.
主要方法:
- 使用定量实时PCR测量基因表达.
- 研究包括50名接受药物治疗的患者,25名未服用药物的患者和50名对照患者.
- 进行了接收器操作特征 (ROC) 曲线分析.
主要成果:
- 与对照组相比,CTNNB1基因表达在未服用药物的患者中显著下降,但在服用药物的患者中没有显著下降.
- 与对照组相比,DANCR,PTCSC3,SNHG5和CCAT2基因的表达在接受药物治疗和未服用药物的患者中显著增加.
- 这四种 lncRNAs 具有很高的诊断能力 (≥80%的特异性和敏感性).
结论:
- 与Wnt/β-catenin通路相关的lncRNAs在精神分裂症患者的周围血液中失调.
- 这些lncRNAs有望成为精神分裂症诊断的潜在生物标志物.
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