心血管健康与代谢功能障碍相关的脂肪性肝病之间的关联:全国性的横截面研究
Lian-Zhen Huang1, Ze-Bin Ni1,2, Wei-Feng Huang1
1Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, No. 55 Zhenhai Road, Xiamen, 361003, China.
Journal of health, population, and nutrition
|January 13, 2025
概括
改善心血管健康 (CVH) 与降低代谢功能障碍相关的脂肪性肝病 (MASLD) 风险有关. 更高的人生生活.
科学领域:
- 研究心血管健康和肝脏疾病的交叉点.
- 专注于与代谢功能障碍相关的脂肪性肝病 (MASLD) 和心血管健康 (CVH).
背景情况:
- 关于心血管健康 (CVH) 与代谢功能障碍相关的脂肪性肝病 (MASLD) 之间的关系的证据有限.
- MASLD是一个日益严重的公共卫生问题,具有复杂的风险因素.
研究的目的:
- 检查心血管健康 (CVH) 与患有代谢功能障碍相关脂肪性肝病 (MASLD) 的风险之间的关联.
- 探索CVH指标和MASLD风险之间的剂量反应关系.
主要方法:
- 利用了来自美国国家健康和营养检查调查 (2017年至2020年3月) 的5680名美国成年人 (≥20岁) 的数据.
- 评估心血管健康 (CVH) 使用生命的基本8 (LE8) 评分.
- 使用加权后勤回归和限制立方线来分析LE8分数与MASLD流行之间的关联.
主要成果:
- 在研究人群中,MASLD的患病率为36.83%.
- 通过LE8得分表示的更高的心血管健康水平 (CVH) 与较低的MASLD几率 (或中度CVH:0.50;或高CVH:0.21,vs低CVH) 有显著的关联.
- 在LE8得分和MASLD风险之间发现了显著的逆剂量反应关系,LE8得分增加10个点将MASLD几率降低32% (OR:0.68).
结论:
- 通过LE8得分来衡量最佳心血管健康,与降低代谢功能障碍相关的脂肪性肝病 (MASLD) 风险密切相关.
- 促进更好的心血管健康可以作为预防或减轻MASLD的策略.
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