口腔微生物群多样性与全因死亡率之间的关联:NHANES的一项纵向研究,2009-2012年
Ju Yu1, Bo Lin1, Zhanqiang Zhang1
1Department of Thyroid Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
BMJ open
|January 14, 2025
概括
通过安普利康序列变异 (ASV) 测量较高的口腔微生物群多样性,与所有原因死亡率的显著减少有关. 这种保护性关联甚至在具有社会经济劣势和较差口腔健康的个体中也被观察到.
科学领域:
- 微生物组研究的研究.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 口腔微生物群的多样性越来越多地被认为对整体健康的作用.
- 了解口腔健康和死亡率之间的联系对于公共卫生倡议至关重要.
研究的目的:
- 调查口腔微生物群多样性与全因死亡率之间的关联.
- 为了确定更高的口腔微生物群多样性是否有助于预防死亡率.
主要方法:
- 基于人口的队列研究,使用美国国家健康和营养检查调查数据 (2009-2012).
- 包括8224名具有有效口腔微生物组数据和到2019年生存后续的参与者.
- 通过安普利康序列变异 (ASV) 测量口腔微生物群多样性;用于分析死亡风险的Cox比例危险回归.
主要成果:
- 较高的ASV数量与社会经济不利,口腔健康不佳和吸烟有关.
- 与最低四分位数相比,ASV数的第三和第四四分位数显示所有原因死亡率显著降低 (HR=0.55和HR=0.58,分别).
- 观察到一种剂量与反应的关系,保护作用在120 ASVs以上停滞不前.
结论:
- 更高的口腔微生物群多样性显著与所有原因死亡率的大幅降低有关.
- 这种保护作用存在,尽管与社会经济劣势和更差的口腔健康有关.
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