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系统性硬化和特征分析患者的轻度认知障碍

Wuriliga^1,2, Dong Xu³, Yang He⁴

¹Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing.

Rheumatology (Oxford, England)

|January 14, 2025

概括

轻度认知障碍 (MCI) 影响超过60%的系统性硬化症 (SSc) 患者,通常与低教育,营养不良和较高的ANA阳性度有关. 这些发现凸显了风湿病学家需要在SSc护理中解决认知健康的问题.

科学领域:

神经学神经学
免疫学免疫学免疫学
类风湿病学类风湿病学

背景情况:

神经系统损伤是系统性硬化症 (SSc) 的新兴问题.
轻度认知障碍 (MCI) 越来越被认为是SSc患者的潜在并发症.

研究的目的:

调查SSc患者中MCI的患病率和特征.
确定与SSc.认知功能障碍相关的人口和临床因素.

主要方法:

用蒙特利尔认知评估 (MoCA-BJ) 的北京版本评估了103名SSc患者和97名健康对照.
认知功能,人口统计数据和临床特征在各组之间进行了比较.
分析了临床变量与MoCA-BJ得分之间的关联.

主要成果:

与健康对照组相比,SSc患者的MoCA-BJ得分明显较低 (24对26,P<0.001).
在61.2%的SSc患者中诊断出MCI (MoCA-BJ ≤25),对照组为27.8%.
患有MCI的SSc患者表现出较低的教育程度,血清蛋白/白蛋白减少和较高的ANA阳性.

结论:

在SSc患者中,MCI的患病率很高,因此需要由类风湿病学家给予注意.
教育水平较低,营养不良和高的ANA阳性是SSc认知障碍的危险因素.
这些发现表明,干预措施的潜在目标是改善SSc.的认知结果.

关键词:

蒙特利尔认知评估蒙特利尔认知评估这就是为什么SSc SSc 轻度的认知障碍轻度的认知障碍

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