确定腹期间吐的危险因素:对补充剂随机试验的二次分析
Jeffrey G Edwards1, Pratibha Dhingra2, Enju Liu3
1Department of Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.
Journal of pediatric gastroenterology and nutrition
|January 14, 2025
概括
较低的剂量用于儿童急性腹,可以降低吐风险. 脱水,体重不足和轮状病毒疫苗接种等因素增加了吐的可能性,指导了更好的患者监测.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 营养科学 营养科学
- 传染病流行病学 传染病流行病学
背景情况:
- 补充是有效的急性腹,但可以增加吐.
- 以前的试验表明,较低的剂量可以减少吐,而不会影响疗效.
- 进行了二次分析,以确定在接受治疗腹的儿童中与吐相关的因素.
研究的目的:
- 确定与接受补充剂的急性腹儿童吐相关的社会人口学和临床因素.
- 确定整体吐,与治疗方案相关的吐和与治疗方案无关的吐的危险因素.
- 为了在急性腹的儿童中管理补充剂的临床实践中提供信息.
主要方法:
- 一项随机,双盲对照试验的二次分析,该试验涉及印度和坦桑尼亚的4500名6-59个月龄的儿童.
- 逻辑双项回归模型用于计算吐的相对风险 (RRs) 和95%置信区间 (CI).
- 对多种人口和临床特征进行调整的分析.
主要成果:
- 吐发生在26.7%的儿童 (1203/4500).
- 与吐风险增加相关的因素包括脱水 (RR: 1.45),体重不足 (RR: 1.22),接种轮状病毒疫苗 (RR: 1.89) 和家庭财富增加 (RR: 1.17).
- 高龄和较低的剂量与吐风险降低有关.
结论:
- 年幼,体重不足或脱水的儿童在接受急性腹的补充剂时,吐的风险更高.
- 识别这些风险因素可以进行有针对性的监测,以防止经常性脱水和不充分的饮食摄入.
- 临床提供者可以利用这些发现来优化治疗,并改善弱势儿童的治疗结果.
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