中年和老年人的心脏代谢多病症和痴呆开始:种族/种族差异
Siting Chen1, Ana R Quiñones1,2, Corey L Nagel3
1OHSU-PSU School of Public Health, Portland, Oregon, USA.
概括
心脏代谢多病症显著增加痴呆风险,特别是在黑人和西班牙裔成年人中. 对这些情况的干预可以帮助减少来自少数群体的老年人痴呆的发病率.
科学领域:
- 老年学与公共卫生
- 心血管和新陈代谢健康
- 神经退行性疾病研究研究
背景情况:
- 美国的种族/少数民族群体表现出更高的心脏代谢多病率.
- 这些群体也面临痴呆发病的风险较高.
- 这项研究调查了不同种族/民族群体内心脏代谢条件和痴呆风险之间的相互作用.
研究的目的:
- 评估心脏代谢多病症和痴呆发病之间的关联.
- 为了检查这些关系在美国中年和老年人的全国代表队伍内.
- 为了确定基于种族/种族的差异性风险.
主要方法:
- 利用了来自健康和退休研究 (1998-2018,N=7,960) 的数据.
- 采用离散时间生存模型来评估痴呆发病风险 (Langa-Weir分类).
- 对种族/种族,慢性疾病类别,年龄,性别,教育,财富,BMI和代理身份进行控制.
主要成果:
- 患有心脏代谢多病症的参与者表现出最高的痴呆发病风险 (HR: 3.27).
- 与没有疾病相比,代谢 (HR:1.83) 和心血管 (HR:1.81) 多病症也增加了痴呆症的风险.
- 患有心脏代谢多病症的黑人 (HR:6.40) 和西班牙裔 (HR:4.90) 参与者比没有疾病的白人成年人患痴呆症的风险要高得多.
结论:
- 种族/民族少数群体的人面临着不成比例地更高的痴呆风险.
- 心脏代谢多病症显著放大痴呆症风险,特别是在黑人和西班牙裔人口中.
- 针对心脏代谢疾病的有针对性的干预措施对于减轻老年人痴呆风险至关重要,特别是那些来自少数群体的老年人.
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