心脏功能和冠状动脉斑块在男性化性别肯定激素治疗后的发展:一项前性队列研究
Laust Frisenberg Buhl1,2, Marianne S Andersen1, Jan Frystyk1,2
1Department of Endocrinology, Odense University Hospital, Odense, Denmark.
Andrology
|January 14, 2025
概括
雄性化性别肯定激素治疗可能会影响心脏健康. 开始治疗后,透析功能下降,而心脏结构和冠状动脉斑块保持稳定. 建议进一步进行心血管监测.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 肯定性别的护理.
背景情况:
- 心血管疾病的风险与心肌功能障碍和冠状动脉斑块有关.
- 雄性化性别肯定激素治疗 (GAHT) 可能会增加心血管风险.
- 需要进行前性研究来评估GAHT期间的心血管结果.
研究的目的:
- 评估心脏形态的变化,收缩和放缩功能,以及在男性化GAHT期间冠状动脉斑块的发展.
- 为了比较GAHT-naïve和GAHT正在进行的跨男性个体之间的结果.
主要方法:
- 对47名跨男性个体的前性研究 (15名曾经接受过GAHT,32名正在接受GAHT).
- 通过心声学评估心脏形态,缩和腹缩功能.
- 冠状动脉化和斑块用计算机断层扫描血管学评估.
主要成果:
- 在GAHT-naïve个体中,治疗开始后的扩张功能下降 (p<0.05).
- 在这两组中都没有观察到心脏形态,缩功能或冠状动脉斑块形成的显著变化.
- 长期接受GAHT治疗的个体与未经GAHT治疗的个体相比,在基线上表现出更大的左心室尺寸.
结论:
- 雄性化的GAHT启动与扩张性功能下降有关.
- 在研究期间,心脏形态,缩功能和冠状动脉斑块发育保持稳定.
- 长期的GAHT参与者左心室尺寸更大,这表明潜在的心脏重塑.
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