2型糖尿病中总抗氧化剂状况和其他生化参数的趋势:一种病例对照研究
Remah Salih Al-Salman1,2, Mohammad M Al-Ahmad1,2, Hiba Alameri3
1Clinical Pharmacy, College of Pharmacy, Al Ain University, Al Ain, 64141, United Arab Emirates.
Current diabetes reviews
|January 14, 2025
概括
总抗氧化剂状态 (TAS) 在2型糖尿病 (T2DM) 患者中较高,这些患者患有伴随性疾病,如失脂血症和小albuminuria. 这表明,TAS在管理T2DM方面可能很重要,因此需要进一步研究.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 生物化学 生物化学
背景情况:
- 氧化应激与2型糖尿病 (T2DM) 病理生理学有关.
- 了解影响T2DM进展的因素对于有效管理至关重要.
研究的目的:
- 调查血清总抗氧化剂状态 (TAS) 与T2DM并发症的相关性.
- 评估TAS与生化参数和疾病持续时间的关系.
- 评估导致T2DM流行和生物化学趋势的因素.
主要方法:
- 对246名T2DM患者进行了回顾性观察性研究.
- 从诊断实验室系统中检索的数据.
- 使用SPSS进行统计分析.
主要成果:
- 在男性,≥45岁,中东族裔,BMI≥25,家族病史,高血压和脂质失调中,T2DM的患病率更高.
- 在患有并发症的患者中,TAS显著更高,特别是失脂症和微专尿症 (p<0.05).
- TAS与大多数T2DM生化参数 (FBG除外) 有弱相关性,与BMI (p<0.05) 有负相关性.
- 高血压患者的白蛋白与肌素的比率 (ACR) 高于高血压患者;疾病持续时间与ACR显著相关 (p<0.001).
- 尿酸水平在患有微专尿症的患者中较高 (p<0.001).
结论:
- 患有脱脂症和小albuminuria的患者的TAS升高表明尿酸和降脂剂等因素的影响.
- 在T2DM管理中,TAS可能会发挥重要作用.
- 需要进一步的研究来阐明TAS在T2DM中的作用.
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