通过优化工艺和配方变量,开发稳定和水溶性纳米悬浮,包括BCS IV类药物
Surya Goel1,2, Vijay Agarwal2, Monika Sachdeva2
1Dr. APJ Abdul Kalam Technical University, Vistar Yojna, Naya Khera, Jankipuram, Lucknow, Uttar Pradesh, India.
Recent patents on nanotechnology
|January 14, 2025
概括
这项研究开发了一种稳定纳米悬浮,用于可溶性较差的药物 - - 甲,显著提高其溶解和生物可用性. 优化的配方证明了药物释放和稳定性的改善,为BCSIV类药物提供了有前途的方法.
科学领域:
- 制药科学 制药科学
- 纳米技术纳米技术
- 药物输送系统 药物输送系统
背景情况:
- 纳米悬浮是有效的改善溶解和生物可用性不容易溶解的药物.
- 在优化纳米悬浮配方以提高药物输送方面仍然存在挑战.
- 作为BCS第四类药物之一的甲基,存在溶解和生物可用性问题.
研究的目的:
- 设计,开发和优化用于chlorthalidone的稳定纳米悬浮剂.
- 描述影响纳米悬浮性质的配方和工艺变量.
- 为了评估在体外药物释放和优化的chlorthalidone纳米悬浮的稳定性.
主要方法:
- 甲基纳米悬浮剂是使用组合的自上而下的和自下而上的方法来制备的.
- 多质聚合物 (L-64,F-68,F-127,F-108) 被作为稳定剂进行了研究.
- 优化了关键的过程变量 (超声波,度) 和配方参数.
主要成果:
- 一个优化的配方使用了Pluronic F-68 (0.6% w/v) 和chlorthalidone (4 mg/ml).
- 优化的纳米悬浮体具有110nm的粒子大小和27.5mV的泽塔电位.
- 实验室药物释放量增加了三倍 (88% vs 27%在90分钟内),配方在4°C和25°C稳定了六个月.
结论:
- 组合的上下和自下而上的制造对于口腔纳米悬浮是有效的.
- 这种方法成功地解决了可溶性较差的BCSIV类药物,如甲的溶解率问题.
- 开发的chlorthalidone纳米悬浮提供了增强的生物利用性和稳定性.
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