怀孕期间口服皮质类固醇的现实世界使用模式:韩国一项全国性基于人口的研究
Jeongin Oh1, Yongtai Cho1, Jung Yeol Han2
1School of Pharmacy, Sungkyunkwan University, Suwon, Korea.
Journal of Korean medical science
|January 14, 2025
概括
口服皮质类固醇 (OCS) 在怀孕期间通常使用,使用量从2010年到2021年增加. 处方主要用于急性呼吸道和皮肤疾病,其模式表明在怀孕后停止治疗.
科学领域:
- 药物监督 药物监督 药物监督
- 产科和妇科 产科和妇科
- 公共卫生 公共卫生
背景情况:
- 在怀孕期间,口服皮质类固醇 (OCS) 经常被处方.
- 在孕妇群体中使用OCS的模式及其适用性并未得到充分记录.
- 了解OCS的使用对于孕产妇和胎儿的健康结果至关重要.
研究的目的:
- 描述韩国孕妇使用OCS的趋势.
- 确定怀孕期间OCS处方的主要适应症.
- 分析OCS在整个妊娠期间使用的时间模式.
主要方法:
- 从2010年到2021年使用韩国医疗保险审查和评估数据库进行的回顾性队列研究.
- 包括4,574,294个怀孕来分析OCS暴露.
- 描述性统计数据以确定患病率,常见的OCS药物,适应症和处方时间.
主要成果:
- 6.2%的怀孕涉及OCS暴露,在2010年至2021年期间,每年患病率从4.98%上升至6.65%.
- 甲基prednisolone和prednisolone占OCS使用的90%,处方时间中位数为四天.
- 常见的适应症包括呼吸道和皮肤疾病;与怀孕相关的疾病的处方在2017年后增加,与不孕症治疗覆盖率有关.
结论:
- 在怀孕期间使用OCS是常见的,并且在增加,主要用于急性疾病.
- 处方模式表明,在怀孕确认后,人们倾向于停止OCS.
- 需要进一步的研究来评估OCS在孕妇中的安全性.
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