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体重变化轨迹的模式和治疗反应在一个综合成人初级保健体重管理实践中的重量变化轨迹
Anita Ganti1, Shanna Tucker2, Afua Takyi3
1Division of General Internal Medicine Weill Cornell Medicine New York New York USA.
Obesity science & practice
|January 14, 2025
概括
识别影响减肥变异性的因素是有效的肥胖干预措施的关键. 较少的访问和抗肥胖药物与较差的结果有关,这表明有针对性的支持至关重要.
科学领域:
- 肥胖研究的研究.
- 临床实践中的临床实践
- 体重管理 体重管理
背景情况:
- 对肥胖干预措施的个人反应有很大差异.
- 预测减肥的因素的早期识别对于临床实践是必要的.
研究的目的:
- 评估与个体变异性相关的因素,以应对体重管理计划.
- 确定患者子组及其体重变化轨迹.
主要方法:
- 在初级保健重量管理实践中对患者的回顾性分析 (2012-2020年).
- 混合模型,半参数型基于组的建模用于定义超过18个月的体重变化轨迹.
- 分析初始体重减轻的百分比和至少5%初始体重减轻的概率.
主要成果:
- 确定了四种体重变化轨迹:体重增加者,最初的抵抗者,早期的维护者和稳定的成就者.
- 根据5%体重减轻的概率定义了三个组:最小迟反应者,中度反应者和高早期反应者.
- 年龄较小,非西班牙裔黑人种族,更少的随访,更少的抗肥胖药物 (AOMs) 与实现5%体重减轻的可能性较低有关.
结论:
- 体重增加者和最小延迟反应者显示出与可修改因素相关的不同的轨迹:治疗次数和AOMs.
- 早期针对治疗访问和AOMs可能会改善减肥结果.
- 个性化干预对于优化临床环境中的体重管理至关重要.
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