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具有非凡的NIRF/光声成像性能和光热瘤治疗功效的预先色剂

Liu Shi^1,2, Zhenzhou Chen^1,3, Jiaxin Ou¹

¹Guangdong Provincial Key Laboratory of New Drug Screening, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism and Guangdong-Hong Kong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.

Acta pharmaceutica Sinica. B

|January 14, 2025

概括

这项研究引入了S-NBD,这是一种用于检测宫癌中的生物醇的新型双模式探针. 该探针可实现有效的光热疗法 (PTT),从而完全切除瘤而不会复发.

科学领域:

生物医学工程生物医学工程
在瘤学瘤学.
医疗成像医学成像

背景情况:

宫癌对健康造成重大负担,需要超越传统手术和化疗的先进治疗方法.
现有的疗法往往会导致严重的副作用,导致需要针对性和不那么侵入性的方法.
光热疗法 (PTT) 为癌症治疗提供了一个有前途的替代方案,对健康组织的损害最小.

研究的目的:

开发一种新的双模式近红外光 (NIRF) /光声学 (PA) 探针,用于生物醇检测和PTT.
通过将生物醇检测与PTT集成来增强瘤向和最大限度地减少副作用.
评估该探针在宫癌诊断和治疗中的in vivo疗效.

主要方法:

开发一种基于二异相的双模式探头 (S-NBD),具有NIRF/PA功能.
探测器光学属性的表征,包括辐射波长和斯托克斯转移.
评估探针的光热转换效率和in vivo瘤切除疗效.

主要成果:

S-NBD探测器显示出高发射波长 (838 nm) 和大斯托克斯转移 (178 nm) 以有效检测生物乙醇.
探测器显示光热转换效率高达67.1%.
使用探针进行激光照射,在体内实现了完全的宫瘤切除,没有复发.

结论:

开发的S-NBD探头是生物醇成像和子宫癌中PTT的开创性工具.
这种双模式探针提供了改进的瘤诊断和治疗能力.
将NIRF/PA成像与PTT整合,为妇科恶性瘤提供了一个新的治疗策略.

关键词:

生物乙醇检测检测器宫癌是发生在宫癌的原因之一.接近红外光 (NIRF) 成像成像光声学 (PA) 成像成像光热疗法 (PTT) 是一种光热疗法.

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