一种共同注册方法,以验证乳房外科腔内的in vivo光学连贯性断层扫描
Rowan W Sanderson1,2, Renate Zilkens1,3, Peijun Gong1,2
1BRITElab, Harry Perkins Institute of Medical Research, QEII Medical Centre Nedlands and Centre for Medical Research, The University of Western Australia, Perth, Australia.
Heliyon
|January 14, 2025
概括
这项研究引入了一种新方法,用于精确验证乳腺癌手术的体内光学连贯性断层扫描 (OCT). 该技术准确地将OCT图像映射到组织学,改善了手术期间的残留癌症检测.
科学领域:
- 医疗成像医学成像
- 在瘤学瘤学.
- 手术技术 手术技术
背景情况:
- 用放射治疗进行乳腺保护手术是早期乳腺癌的标准.
- 20-30%的再切割率与积极的瘤边缘有关.
- 目前的业内利评估缺乏广泛采用和直接验证.
研究的目的:
- 开发和验证一种可靠的方法,以共同记录体内光学连贯性断层扫描 (OCT) 扫描与相应的组织学.
- 准确评估使用OCT在手术腔中的残留乳腺癌.
- 克服在体内OCT间接验证方法的局限性.
主要方法:
- 使用手持式光学连贯性断层扫描 (OCT) 探针进行体内成像.
- 开发了一种共同注册技术,使用ex vivo OCT,手术作为信托标记,并重叠扫描.
- 将体内视野扩大到15 x 15 mm2.
- 在直接与体内扫描组织相对应的腔片上进行了组织学.
主要成果:
- 在16名患者的139个体内OCT扫描中的78%的成功联合注册.
- 展示了一种用于直接验证体内OCT成像性能的方法.
- 提交了详细的案例分析,包括使用定量微弹性图.
结论:
- 提出的共同注册方法使得在外科手术边缘评估中准确验证体内海洋和海域国家/地区.
- 这种技术有可能改善残留乳腺癌的检测,降低再切割率.
- 需要在外科瘤学中进一步开发和应用OCT.
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