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Updated: Jun 6, 2026

Use of Recombinant Fusion Proteins in a Fluorescent Protease Assay Platform and Their In-gel Renaturation
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艾滋病毒OctaScanner:一种机器学习方法,揭示HIV-1蛋白酶基质中的蛋白解裂动态

Kashif Iqbal Sahibzada1,2, Shumaila Shahid3, Mohsina Akhter4

  • 1College of Biological Engineering, Henan University of Technology, Zhengzhou 450001, China.

Journal of chemical information and modeling
|January 14, 2025
PubMed
概括

艾滋病毒蛋白酶突变导致药物耐药性. 一个新的机器学习工具HIV OctaScanner准确地预测了切割部位,有助于开发下一代抗逆转录病毒疗法.

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Inhibitors of Virion Maturation and Assembly01:19

Inhibitors of Virion Maturation and Assembly

As part of their replication cycle, certain viruses synthesize long precursor proteins called polyproteins within infected host cells. In human immunodeficiency virus (HIV), two major polyproteins are produced: Gag and Gag-Pol. The Gag polyprotein supplies the structural components of the virus, while Gag-Pol includes essential viral enzymes such as reverse transcriptase, integrase, and protease. After synthesis, these polyproteins move to the host cell membrane, where they assemble into an...