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内瘤异质性预测了白血病主导性肺腺癌的预后

Benedikt Niedermaier^1,2, Michael Allgäuer^2,3, Thomas Muley^2,4

¹Department of Thoracic Surgery, Thoraxklinik, Heidelberg University Hospital, Heidelberg, Germany.

Thoracic cancer

|January 14, 2025

概括

斑疹主导性腺癌 (LPA) 显示出显著的内异质性. 在I期LPA中存在微毛囊和固体成分等高风险生长模式,与较差的无病生存率有关.

科学领域:

肺部医学肺部医学
在瘤学瘤学.
手术病理学手术病理学

背景情况:

斑疹主导性腺癌 (LPA) 是侵袭性肺腺癌的风险最低的亚型,预后一般良好.
在LPA中的瘤内部异质性可能会影响患者的治疗结果.
了解这些变异对于准确的预后分层至关重要.

研究的目的:

为了研究I阶段LPA瘤中生长模式的异质性.
评估不同亚组织学对LPA生存结果的影响.
为了确定与预后相关的特定生长模式.

主要方法:

对75名患有I期LPA且经过手术切除的患者 (2010-2022) 的回顾性分析.
详细报告增长模式比例 (世卫组织分类) 的5%的增量.
高风险生长模式 (微毛囊,固体) 与T阶段和无病生存率的相关性.

主要成果:

所有LPA瘤都表现出一种占主导地位的形图案 (中位数为70%),具有不同比例的侵入性成分,包括状,乳头状,微乳头状和固体图案.
微毛囊和固体生长模式的存在与较高的T阶段相关.
患有高风险 (微毛囊/固体) 组件的患者的5年无病存活率 (73%) 与低风险皮/低风险病例 (95%) 相比显著降低.

结论:

第一个阶段的LPA在生长模式中表现出显著的内异质性.
这种异质性,特别是微毛囊和固体成分的存在,允许预后分层.
在LPA中,微毛囊和固体生长模式与较差的无病生存率有关,突出显示了它们的临床意义.

关键词:

组织学组织学组织学类的类动物.肺癌是一种肺癌.预后预后预后幸存率幸存率生存率

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