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Updated: Jun 2, 2025

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
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与肥胖相关的MRAP2变体会损害多个MC4R介导的信号通路

Rachael A Wyatt1,2, Aqfan Jamaluddin1,2, Vinesh Mistry1

  • 1Department of Metabolism and Systems Science, University of Birmingham, Birmingham, B15 2TT, United Kingdom.

Human molecular genetics
|January 14, 2025
PubMed
概括

与肥胖相关的黑色皮质素-2受体辅助蛋白2 (MRAP2) 的遗传变异会损害黑色皮质素-4受体 (MC4R) 的多个信号通路,影响食欲调节. 对cAMP和IP3信号的全面评估对于确定变种病原性至关重要.

关键词:
与G蛋白结合的受体是G蛋白结合的受体.在MRAP2的变体中.肥胖问题 肥胖问题信号传输 信号传输

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