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翻译纳米机器人突破了生物膜

Alzbeta Ressnerova^1,2, Zbynek Heger^2,3, Martin Pumera^1,4,5,6

¹Central European Institute of Technology, Brno University of Technology, Purkynova 123, CZ-612 00, Brno, Czech Republic. pumera.research@gmail.com.

Chemical Society reviews

|January 14, 2025

概括

开发纳米机器人用于体内治疗需要克服生物膜障碍. 本综述详细介绍了成功的纳米机器人药物输送的四个关键膜和推进策略.

科学领域:

翻译的纳米机器人技术
生物医学工程生物医学工程
药物输送系统是药物输送系统.

背景情况:

生物膜在体内纳米机器人介导的治疗中面临着重大挑战.
纳米机器人的成功临床转化取决于它们导航和跨越这些生物障碍的能力.
纳米机器人穿越膜的策略在当前的科学文献中代表性不足.

研究的目的:

审查和识别纳米机器人必须穿过的关键生物膜,以进行体内治疗应用.
讨论各种纳米机器人推进机制 (化学,物理,混合) 相关的膜交叉.
突出设计挑战和跨学科合作在翻译纳米机器人的需要.

主要方法:

文献综述侧重于纳米机器人和生物膜相互作用.
识别和描述四个关键的生物学障碍:皮肤/粘膜/血管系统的入口,内皮穿越,血膜的入口和溶酶体的逃逸.
分析不同的纳米机器人推进系统,以克服这些障碍.

主要成果:

确定了四个关键的生物膜:入口障碍,内皮,血膜和溶酶体.
在膜穿越的背景下,讨论了各种化学,物理和混合推进机制.
对in vivo纳米机器人应用和膜交叉的设计挑战进行了批判性评估.

结论:

克服生物膜对于有效的基于纳米机器人的体内治疗至关重要.
进一步的研究和跨学科合作对于推进精准医学的转化纳米机器人至关重要.
为纳米机器人穿越膜开发强大的战略将打开新的治疗可能性.

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